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Temporary Suspension of International Shipping of Live Animals
 July 08, 2024
Effective immediately: Due to continued weather-related issues negatively impacting the safety, reliability, and cost of shipping, we are temporarily suspending international shipments of live animals.   Orders may still be placed but they will not be filled until after September 1, 2024. We apologize for any inconvenience and thank you for your understanding.

Weather and high temperatures are also affecting domestic shipping so expect delays. The welfare of the animals is our top priority. 
Laboratory Animal Genetic Reporting (LAG-R) Guidelines Published
 July 07, 2024
The LAG-R framework (Laboratory Animal Genetic Reporting) is a set of guidelines to support more complete documentation of the genetic make-up of animals of all species that are used in research, with the aim of bolstering reproducibility, reliability, and overall scientific rigor. See Nature Communications (
RRRC at Allied Genetics Conference (TAGC24)
 February 20, 2024
Stop by Booth 626 in the Exhibitor Hall at the Allied Genetics Conference (TAGC24) in National Harbor/Washington DC Metro Area on March 6-10, 2024 to discuss how the RRRC can help facilitate your research.

GRCr8: A new rat reference assembly is now available.
 February 05, 2024
GRCr8 (GenBank NCBI # GCA_036323735.1) is the latest version of the rat reference genome assembly. See the Genome Reference Consortium (GRC) blog for more details.
Happy World Rat Day!
 April 04, 2023
April 4, 2023 is World Rat Day!  The RRRC would like to acknowledge the important contributions to science and medicine made possible by the use of rats in biomedical research.

KSOM-R supports both mouse and rat preimplantation embryo development in vitro.
Men H, Amos-Landgraf JM, Bryda, EC, Franklin, CL. (2023) Theriogenology 198:69-74.

The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats. Chesney KL, Men H, Hankins MA, Bryda EC.(2021) Physiol Genomics. 53:269-281.

Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes. Men H, Hankins MA, Bock AS, Beaton BP, Davis DJ, Chesney KL, Bryda EC.(2021) Mamm Genome.32:173-182.

Media optimization to promote rat embryonic development to the blastocyst stage in vitro.
Men H, Stone BJ, Bryda EC. (2020) Theriogenology 151:81-85.

A Non-surgical Embryo Transfer Protocol for Fresh and Cultured Blastocysts in Rats. Stone BJ, Steele KH, Men H, Srodulski SJ, Bryda, EC, Fath-Goodin, A. (2020) J Am Assoc Lab Anim Sci 59:488-495.

Using vaginal impedance measurement to stage estrous in rats given luteinizing hormone releasing hormone (LHRH) agonist. Chesney KL, Chang C, Bryda EC. (2020) J Am Assoc Lab Anim Sci 59:282-287.

A novel conditional ZsGreen-expressing transgenic reporter rat strain for validating Cre recombinase expression. Bryda EC, Men H, Davis DJ, Bock AS, Shaw ML, Chesney KL, Hankins MA. (2019) Scientific Reports 9:13330.

Letter to the editor announcing the availability of RCS and transgenic rats with P23H and S334ter rhodopsin mutations with inherited retinal degenerations. Bryda EC and LaVail M. (2019) Exp Eye Res. 178:176.

Rat Genome and Model Resources. Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M. (2017) ILAR Journal. 58:42–58.

Derivation of transgene-free rat induced pluripotent stem cells approximating the quality of ES cells. Li S, Lan H, Men H, Wu Y, Li N, Capecchi MR, Bryda EC, Wu S. (2017) Stem Cells Translational Medicine 6:340-351.

Efficient Generation of Selection-Gene-Free Rat Knockout Models by Homologous Recombination in ES Cells. Lan H, Li S, Guo Z, Men H, Wu Y, Li N, Bryda EC, Capecchi M, Wu S. (2016) FEBS Letters 590:3416-3424.

Rapid conditional ablation model for hemolytic anemia in the rat.
Hanson MM, Liu F, Dai S, Kearns A, Qin X, Bryda EC. (2016) Physiological Genomics 48:626-632.

Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis. Hansen SA, Hart ML, Busi S, Parker T, Goerndt A, Jones K, Amos-Landgraf JM, Bryda EC. (2016) Dis Model Mech. 9(10):1139-1146.

Post-thaw ATP supplementation enhances cryoprotective effect of iodixanol in rat spermatozoa. Kim, S, Hooper, S, Agca, C, Agca, Y. (2016) Reprod Biol Endocrinol. 14:5.

Differential Susceptibility to Colorectal Cancer due to Naturally Occurring Gut Microbiota.
Ericsson AC, Akter S, Hanson MM, Busi SB, Parker TW, Schehr RJ, Hankins MA, Ahner CE, Davis JW, Franklin CL, Amos-Landgraf JM, Bryda EC. (2015) Oncotarget 6:33689-33704.

Electroejaculation of chimeric rats. McCoy MR, Montonye D, Bryda EC. (2014) Lab Anim (NY) 42:203-5.

Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells. Bock AS, Leigh ND, Bryda EC. (2014) In Vitro Cell Dev Biol Anim.50:572-579.

Derivation of a Germline Competent Transgenic Fischer 344 Embryonic Stem Cell Line. Men, H and Bryda, EC. (2013) PLoS One 8:e56518.

Germline Transmisson of a Novel Rat Embryonic Stem Cell Line Derived from Transgenic rats. Men H. Bauer BA, Bryda EC. (2012) Stem Cells Dev. 21:2606-2612.

Changes in rat spermatozoa function after cooling, cryopreservation and centrifugation processes. Kim S, Agca C, Agca Y. (2012) Cryobiology.  65:215-223.

Effects of various physical stress factors on mitochondrial function and reactive oxygen species in rat spermatozoa. Kim S, Agca C, Agca Y. (2013) Reprod Fertil Dev. 25:1051-1064.