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Animal Models and New Approach Methodologies (NAMs)

July 30, 2025
NAMs are intended to expand our tools for modeling human biology and disease. While this field is rapidly evolving, the need for animal models remains since current alternative approaches cannot accurately replicate or model all biological and behavioral aspects of human disease.  Importantly, animal models serve as vital in vivo controls for the validation and verification of emerging NAMs.  NIH encourages researchers to use complementary approaches as appropriate to promote rigor and reproducibility in scientific studies. Contact the RRRC to see how we can assist with your animal needs as well as support your NAM experiments.  
10.03.2025

Plan ahead for the holidays

The University of Missouri, home of the RRRC, is closed for business for the holidays at the end of December/beginning of January.  Please be aware that we will not be responding to inquiries, providing services or shipping materials from December 22, 2025 through January 2, 2026. 

08.25.2025

Why Research Resource Identifiers (RRIDs) Are Important

RRIDs are unique identifiers for key biological resources, genetically enigineered animals and reagents like antibodies.  Piekniewska et al. document how use of RRIDs improves trackability.  Importantly, better citation practices increase research rigor and reproducibility. 

07.30.2025

Animal Models and New Approach Methodologies (NAMs)

NAMs are lab (e.g., organoids and iPSCs) or computer-based methods intended to expand our tools for modeling human biology and disease. While this field is rapidly evolving, the need for animal models remains, especially for situations where a complex biological system is necessary. In addition, animal models serve as vital in vivo controls for the validation and verification of emerging NAMs.  

02.16.2025

In Need of a New Rat Model?

Need a new rat model?  The RRRC in conjunction with the MU Animal Modeling Core (AMC) can assist with the generation of transgenic rats, create knock-out and knock-in rats using CRISPR/Cas9 technology and genetically manipulate rat embryonic stem cells to make chimeric animals.  Contact us to discuss your rat model needs and how we can help.